Protease-activated receptors differentially regulate endothelial nitric oxide synthase

It has been established that the activation of protease-activated receptor-2 (PAR-2) phosphorylates endothelial nitric oxide synthase (eNOS)-Ser-1177 through a distinct signaling pathway that leads to the production of the potent vascular vasodilator nitric oxide (NO), while PAR-1 activation phosphorylates eNOS-Thr-495 and decreases NO production through a separate pathway. In this study, we have identified a variance in PAR coupling to the signaling pathways that regulate eNOS phosphorylation a...